Evaluation of invitro antidiabetic and hypolipidaemic activities of extracts citrus lemon fruit 615 lemon fruit extract and standard acarbose against. Northeastern canada used against symptoms of diabetes and their biological activity assessed by in vitro bioassays. Antidiabetic activity of pongamia pinnata leaf extracts in. More number of plant and plant products have been scientifically tested and reported to posses anti diabetic activity 2635 examples of herbal medicines with proven anti diabetic activity plant part used. The selected plant extracts were studied for their effect on inhibition of glycosylation of haemoglobin and glucose transport across yeast cells. The antidiabetic activity of the chloroform extract of the plant leaves on chronic treatment of streptozotocininduced niddm non insulin dependent diabetes mellitus model diabetic rats was evaluated and the herb possesses antidiabetic activity. A comparison was made between the action of extracts from different parts. Comparative evaluation of the antidiabetic and hypoglycaemic. Jul 14, 20 therefore, the present study was aimed to investigate in vivo antidiabetic activity of aqueous extract of terminalia paniculata bark aetpb in type 2 diabetic rats. Evaluation of in vitro anti diabetic activity of selected plant extracts sindhu. Antidiabetic activity medicinal plant aegle marmelos. Evaluation of antidiabetic activity of euphorbia hirta.
The duration of each experiment lasted from 1 week to 1 month, and the results were compared with that of the standard. Role of plant antioxidants in diabetes has not been undertaken. The present study was aimed to investigate in vivo, in vitro antidiabetic activity of aqueous extract of terminalia paniculata bark aetpb and characterize its possible phytoconstituents responsible for the actions. Mechanism of action for the drug class inhibition of dpp4 enhances the activity of active glp1, thus increasing glucosedependent insulin secretion and. The present study was designed to investigate the hypoglycemic effect of an aqueous extract of mac st001 a new polyherbal formulation which was given once daily to rats at different doses. In vitro antidiabetic activity of cardiospermum halicacabum leaves extracts by stalin. Antidiabetic herbal drugs and polyherbal formulation used. In single dose study the maximum reduction in serum glucose level was noted at second hour by t. Antidiabetic activity of vinca rosea extracts in alloxan. Diabetes mellitus is a metabolic disorder which is rising globally in rich and developing countries. The present study was designed to investigate the glucose uptake of antidiabetic activity crude nhexane,ethanol, methanol and aqueous leaf.
Type 2 diabetes was induced in rats by streptozotocinnicotinamide 65 mgkg110 mgkg. The aim of this study was to investigate the antidiabetic activity of stem bark of berberis aristata dc familyberberidaceae extract in stzinduced diabetic albino wistar rats. Mp extracts were prepared sequentially with methanol, chloroform and petroleum ether. Phytochemical and in vitro antidiabetic activity of. In the african region this rate is the highest, with 20 million diagnosed diabetics. Pdf in the last few years, there has been an exponential growth in the field of herbal medicine and gaining popularity both in developing and. In vitro toxicity and antidiabetic activity of a newly. Antidiabetic herbal drugs and polyherbal formulation used for. The aim of the present study was undertaken to investigate the hypoglycaemic and antidiabetic effect of single and repeated oral administration of the aqueous extract in normal and streptozotocin induced diabetic rats respectively, serum lipid profile was also examined. There was a dosedependent increase in percentage inhibitory activity against alphaamylase enzyme.
Screening for antidiabetic activity of the ethanolic extract of barleria cristata seeds ranjit singh, p. Reveals that diabetes mellitus increases the plasma glucose level, gradually which is due to insulin dysfunction. It was extracted up to one week with daily 2 hours stirring with a mechanical stirrer. Chapter4 antidiabetic activity of the selected plants by in. F, the pharmacological basis for therapeutic, macmillon, new york, 1985. The antihyperglycaemic activity of petroleum ether extract of cicer arietinum peeca seeds was evaluated at. Original article experimental evaluation of antidiabetic.
Decreased blood glucose levels of the test animals showed that the extract exhibited significant antidiabetic activity, when compared to diabetic control group. In vitro investigation of antidiabetic potential of selected. To evaluate the antidiabetic activity of an aqueous extract of the roots of hemidesmus indicus on blood glucose, serum electrolytes, serum marker enzymes, liver microsomal p450 enzymes, and lipid peroxidation in the liver and kidney of streptozotocininduced diabetic rats. An oral glucose tolerance test ogtt was also performed in experimental diabetic rats. Despite a noticeable progress in the treatment of diabetes mellitus by synthetic drugs, the search for new natural antidiabetic agents is going on. A higher antiinflammatory activity was observed in extract obtained from microwave extraction 64. Chapter4 antidiabetic activity of the selected plants by in vitro models. Chapter4 antidiabetic activity of the selected plants by in vitro models the selected 15 medicinal plants madhuca indica bark, ancardium occidentalis bark, basella alba aerial parts, echinaps echinatus aerial parts, holoptetea integrifolia bark, mangifera indica kernels, caesalpinia bounduc kernels, limonia acidissima bark.
By acute toxic class method swiss albino mice of female sex weighing 2025gms were used for the study. An acute oral toxicity study was performed as per oecd guidelines 423. The antidiabetic effects were found to be dosedependent. Antidiabetic effect of medicinal plants aegle marmelos it belongs to family rutaceae and is a midsized, slender, aromatic, armed, gumbearing tree and has a leaf with three leaflets. Foeniculum vulgare, antidiabetic activity, aqueous extract, streptozotocininduced diabetic rats. In vivo and in vitro antidiabetic activity of terminalia. Antidiabetic activity of costus speciosus rhizome extract against alloxan induced diabetic rats table and fig 1. The phytoconstituents biomarkers present in aetpb were characterized by highperformance liquid chromatography hplc analysis. The animals were divided into diabetic and nondiabetic control groups. Acute toxic class method is a stepwise procedure with use of three animals of a single sex per step.
Antidiabetic activity of alcoholic extract of cinnamomum. The selected plant parts were subjected to solvent extraction and analyzed for their antidiabetic activity using in vitro assays such as. Effect of ethanolic extract of cinnamomum zeylanicum leaves on fasting blood glucose level of alloxaninduced diabetic rats subacute studies. Antidiabetic activity of terminalia catappa leaf extracts ijpt. Effect of ethanolic extract of bougainvillea spectabilis leaves on haematological and serum lipid variables in rats.
Identification and quantification of bioactive compounds present was analysed by hplc. Based on the acute toxicity studies, the dose of plant extract was selected for. Antidiabetic herbal formulations are considered to be more effective for treatment of diabetes. Evidencebased complementary and alternative medicine. The basal fasting blood glucose fbg of the rats was determined and diabetes was induced as described before.
However, antidiabetic activity was seen when the extract and glucose were administered simultaneously and also when the extract was given to the rats 60 min before the glucose. Antidiabetic potential of medicinal plants and their active. Zingiber officinale rhizome aqueous extract were examined at concentrations of 5, 10, 20 and 40 gl. Anti diabetic medicinal plants open access journals.
Identification and quantification of bioactive compounds present was analysed by. Administration of these plant extracts were found to reduce serum glucose level in normal rats both in single and multi dose study. Aqueous extracts of zingiber officinale rhizomes were studied to evaluate their antidiabetic effects on protein glycation and on the diffusion of glucose in vitro in the present study. Medicinal plants with antidiabetic effects cicer arietinum it was reported that the seeds reduced postprandial plasma glucose and were useful in the treatment of diabetes. Antidiabetic activity, glucose uptake stimulation and. This study was aimed to evaluate the antidiabetic and antioxidant activity of a. The antidiabetic activities of the aqueous leaf extract of. Evaluation of antidiabetic activity of euphorbia hirta linn. It is seen in dry forests on hills and plains of northern, central, eastern and southern india, pakistan.
Leguminosae leaf extracts was investigated in alloxaninduced diabetic albino rats. Screening for antidiabetic activity of the ethanolic. The plant extract or phytochemicals have involved in decreasing or increasing or stimulating. Invitro and invivo studies of antidiabetic activity of. The uv absorbance of the glycation reactions was found to be maximum at 24 hrs. Plant species with antidiabetic properties plant based medicinal products have been known to man since ancient times, subbulakshmi and naik, 2001. Pdf in vitro toxicity and antidiabetic activity of a newly developed. Antidiabetic activity of aqueous extract of sigesbeckia orientalis st. Analysis of remedies obtained from different plant parts for diabetes mellitus family botanical name common name parts used.
Evidencebased complementary and alternative medicine hindawi. Okolo rural dwellers in nigeria often resort to herbal remedy and dietary control in the treatment of diabetes mellitus dm. Sep 28, 2012 the present study was designed to investigate the hypoglycemic effect of an aqueous extract of mac st001 a new polyherbal formulation which was given once daily to rats at different doses. Antidiabetic activity of aqueous and methanol extract and fractions of gongronema latifolium leaves in alloxan diabetic rats p. To evaluate the glucose uptake of antidiabetic activity crude nhexane, ethanol, ethanol and aqueous leaf extracts of p. Oral treatment of aetpb using rat oral needle at 100 and 200. In the present study, we have evaluated terminalia chebula, terminalia belerica, emblica officinalis, their combination triphala for their antidiabetic activity and their relation with their antioxidant activity.
Blume was selected which was traditionally used for various ailments like leprosy, antioxidant, secondary syphilis, rheumatism ophthalmic, the folklore claim of hydnocarpus wightiana blume shows that it is having antioxidant properties and antidiabetic activity. Rosacea ranked highly and increased the transport of. Antidiabetic effect of costus speciosus rhizome extract in. In vitro antidiabetic activity of psidium guajava leaves. The methanolic whole plant extract at high dose 500 mgkg exhibited significant antihyperglycemic activity than whole plant extract at low dose 300 mgkg in diabetic rats. Evaluation of antidiabetic and antioxidant activity of. In the present chapter, we propose to investigate the. The present study was designed to investigate the glucose uptake of antidiabetic activity crude nhexane,ethanol, methanol and aqueous leaf extracts of cardiospermum halicacabum. This may be due to an intestinal reduction of the absorption of. Plant based drugs have been used against various diseases since a. In vivo assessment of antidiabetic and antioxidant activities. Antidiabetic effects of natural plant extracts via inhibition of carbohydrate hydrolysis enzymes with emphasis on pancreatic alpha amylase abstract importance of the field. Multiple plant extracts derived products are available in asian herbal markets as antidiabetic agents like.
Introduction diabetes mellitus is the one of the challenging health. In multi dose study from 7th to 11th day, all the extracts significantly p plant parts were subjected to solvent extraction and analyzed for their antidiabetic activity using in vitro assays such as. The increasing prevalence of type 2 diabetes mellitus and the negative clinical outcomes observed with the commercially available antidiabetic drugs have led to the. The aqueous ethanol and butanol extracts have shown significant reduction in blood glucose levels in both glucose loaded and. Screening for antidiabetic activity of the ethanolic extract of. Hypoglycemic activity of the extract was examined in normal and.
Chapter4 antidiabetic activity of the selected plants by. The antidiabetic activity of pongamia pinnata family. Antidiabetic potential of two medicinal plants used in. The aqueous ethanol and butanol extracts have shown significant reduction in blood glucose levels in both glucose loaded and alloxan induced diabetic rats. Significant reduction in glycaemia was observed only when ginseng was taken 40 min before gc in nondiabetic subjects and the same result was seen in diabetic subjects. Antidiabetic activity of the alcoholic extract of the arial part of boerhaavia diffusa in rats. Aegle marmelos, alloxan, antidiabetic, hyperglycemia. A comparison was made between the action of different extracts of p. Plants have been the primary source of drugs and many of the currently available drugs have been directly or indirectly derived from plants. Medicinal plants with potential antidiabetic activity a.
Moringa oleifera has promising antidiabetic and antioxidant. The present study was carried out to evaluate the antidiabetic activity of vinca rosea methanolic whole plant extracts in alloxan induced diabetic rats for 14 days. Models to study in vitro antidiabetic activity of plants. The antidiabetic effect of the plant extract was studied by evaluating the effect of its chronic administration on the blood glucose level of alloxaninduced diabetic rats. Antidiabetic activity of ethanolic extract of hydnocarpus. This extract was used for in vitro and in vivo analysis of antidiabetic activity. Antidiabetic agents from medicinal plants bentham science. Determination of in vitro antidiabetic effects of zingiber. Pdf models to study in vitro antidiabetic activity of. Possible therapeutic potential for diabetic complications curr diabetes rev 2012. Abstract a comparative evaluation of the antidiabetic and hypoglycaemic potential of the extracts from different plant parts of musa paradisiaca mp was carried out in vitro. After 7 days the extract was filtered through muslin cloth and marc was discarded. The results indicate that aqueous extract of mangifera indica possess hypoglycemic activity.
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